Would replacing a battlecarrier's heavy guns with vertical-launch missile cells make the hybrid concept more practical today?
Short answerIt could, but the ship would need a larger, longer hull, substantial missile capacity, and a deck suitable for F-35B and helicopter operations rather than a simple weapon swap in the old layout.
NotesChanging the weapon does not remove the need for a coherent mission design. Vertical-launch cells occupy less mechanically intrusive space than battleship turrets and avoid much of the gun-blast problem around a flight deck. The proposed modern version uses a larger, longer hull with distributed missile capacity and a deck that can launch and recover F-35Bs. Its notional air group includes roughly two dozen F-35Bs and eighteen helicopters, making aviation a primary capability rather than a token addition. This is an aviation ship with strong missile armament, not a direct recreation of the Ise compromise.