Does the size of nuclear submarines show that reactors only make sense in very large ships?
Short answerNo. Nuclear submarines are often large because they perform long-range attack and patrol missions, so their size reflects the role as well as the propulsion system.
NotesMost modern nuclear submarines perform long-range patrol and attack missions that require substantial weapons, sensors, endurance, and habitability. Those roles are compared with the Royal Navy's wartime T-class submarines. Modern conventional submarines more often fill shorter-range jobs analogous to the smaller U class. The size difference therefore reflects mission as well as machinery. Nuclear propulsion should be judged against what the boat must do rather than treated as a technology reserved automatically for any very large warship.