Why warships used unequal turret layouts

Did warship designs ever mix different numbers of guns among their main-battery turrets?

Yes. Italian and U.S. battleships and cruisers used or explored unequal arrangements, although logistics and design complications made the layouts unattractive.

Mixed twin, triple, and quadruple turret arrangements appeared in real designs. Italian and U.S. battleships and cruisers provide examples, although unequal layouts were unattractive from a logistics and design standpoint. The King George V arrangement illustrates complications that a uniform three-quadruple or three-triple battery might have avoided. The follow-up also points to Admiral Hipper, Fiji, and Japanese Kongo-replacement studies as further interwar experiments.