How prepared were U.S. destroyers for U-boats?

How would prewar U.S. destroyers and their doctrine fare against a U-boat?

The U.S. Navy was developing sonar and had capable specialists, but British ASDIC was further advanced and American institutional attention remained focused more heavily on fighting Japan.

The Royal Navy used sloops as a leading institutional home for anti-submarine development while also employing destroyers. Comparable American patrol roles often sat with the Coast Guard, so the U.S. Navy lacked the same sloop-centered structure. American sonar development and specialist thinking were real, and later entry into the war provided extra time to refine them. Those voices nevertheless received too little attention because the service expected a major fleet war against Japan. Institutional ownership could matter as much as possession of a promising technology.