Hood was designed for an earlier war

Did Hood's scale and novel design make her loss an inevitable result of the Royal Navy entering unknown territory?

That simple claim does not hold: Hood was designed for 1910s and 1920s conditions but had not been modernized for the late-1930s and 1940s war she fought.

Hood was not a reckless leap beyond all previous British practice. She was only a few changes removed from earlier designs and was built around expectations formed in the 1910s and 1920s. The combat environment had changed substantially by the late 1930s and early 1940s. The Royal Navy had not completed the modernization needed to adapt her to that later war before she fought Bismarck. The answer therefore locates the problem in the gap between original assumptions and later service conditions rather than in size or novelty alone.