What mattered most in the loss of USS Hornet

How important were the 21 aircraft lost with USS Hornet compared with the carrier and the 140 crew members killed?

The scarce carrier was the most important strategic loss, experienced crew came next, and the aircraft were comparatively easy to replace.

The question identifies 140 crew members killed and 21 aircraft lost with Hornet. The normal preference is to put human loss first, but the shortage of American carriers at that moment gives the hull exceptional strategic importance. The crew's deaths still matter much more than the aircraft loss. For many of the relevant aircraft production lines, replacing those aircraft represented less than a day's output.