Did the loss of SS Central America weaken the Monroe Doctrine?

How did the sinking of SS Central America and the crisis of 1857 affect the Monroe Doctrine?

It did not materially alter the doctrine or American enforcement capacity; the Civil War was the more consequential change.

The financial shock associated with SS Central America did not destroy the United States economy. The Monroe Doctrine itself was not materially altered. American capacity to enforce it remained limited, with no comparable change in what the country could do abroad. Civil War mobilization and economic expansion provide the more consequential comparison.