What prevents a 5,000-6,000-ton Type 21 from using steel and carrying Sea Wolf?
Short answerVery little; the much larger hull should use steel and would have ample margin for Sea Wolf.
NotesGrowing the Amazon class from roughly 3,360 tons full load to 5,000 or 6,000 tons nearly doubles its displacement. At that scale the design should use steel rather than an aluminum superstructure, removing the same strengthening problem, while the added volume should make a Sea Wolf fit practical.