Could Graf Zeppelin's guns stop destroyer attacks?

Would Graf Zeppelin's 150 mm guns let it fight through destroyers in confined waters?

No. The scenario misuses the carrier, ignores escorts and geography, and exposes it to torpedoes, mines, shore batteries, and heavier supporting ships.

The proposed scenario has Graf Zeppelin fighting destroyers while escaping through narrow channels. The reply first challenges the geography and force structure: German control of Denmark and Norway changes the exits, while a carrier should have escorts screening ahead. It also corrects the claim that German 150 mm fire drove off British destroyers attacking Bismarck. Their repeated individual approaches followed Royal Navy night torpedo doctrine. At close range, destroyer torpedoes could mission-kill the carrier, and the Royal Navy could accept destroyer losses to remove such a valuable target. If Germany did not control the narrows, mines and shore batteries would be more credible obstacles than the destroyers the casemate guns were meant to defeat. A supporting British cruiser or battleship would make reliance on the carrier's six-inch battery still less credible.