Fourteen ship losses against the scale of a fictional fleet

How serious is the loss of fourteen ships in Star Trek: Shattered Universe if the wider fleet contains hundreds or thousands?

It probably does not cripple a fleet of that assumed size.

The question describes fourteen ships destroyed with all hands lost, together with numerous fighters, in Star Trek: Shattered Universe. The assessment depends on the assumption that the wider fleet has hundreds or thousands of ships. At that scale, fourteen destroyed hulls are judged unlikely to cause a massive reduction in fleet strength.